PhD Candidate · Microbiology & Immunology · Dartmouth

Sarvesh V. Surve

Geisel School of Medicine at Dartmouth
Gut microbiome science & the probiotic potential
of Bacteroides in cystic fibrosis

10+
Publications
8
Years Research
Sarvesh V. Surve
01 — About

The Scientist
Behind the Work

I'm a PhD candidate at the Geisel School of Medicine at Dartmouth, working in Dr. George O'Toole's lab. My research sits at the intersection of microbial ecology, gut microbiome science, and translational medicine, focused on how gut bacteria can improve outcomes in cystic fibrosis (CF).

My thesis centers on Bacteroides as a potential CF probiotic. I combine experimental evolution, molecular microbiology, culturomics, and bioinformatics to understand how these bacteria adapt in the CF gut.

Before Dartmouth, I trained in India at Symbiosis International University and the University of Mumbai, developing expertise in lactic acid bacteria, probiotic science, and secondary metabolite biosynthesis. In 2025, I attended the Marine Biological Laboratory's Microbial Diversity course at Woods Hole, MA.

Outside the lab, I'm chasing National Parks, Formula 1 races, and the perfect data visualization.

Fun photo 1
Woods Hole · MBL 2025
Fun photo 2
Distracted by a duck
Fun photo 3
Holding a Nobel Prize

Current Position

PhD Candidate · Microbiology & Immunology
Dartmouth College · Hanover, NH
Expected June 2027

Advisor

Dr. George A. O'Toole
Geisel School of Medicine

Google Scholar

View Profile →

Interests

Formula 1 · National Parks · Data visualization · Science history

Core Research Areas

↗ Hover each card to see project photos

🦠

CF Gut Microbiome

Culturomics of colonoscopy samples from CF and non-CF individuals — one of the largest gut culture collections of its kind to understand dysbiosis in cystic fibrosis.

CF Gut Microbiome
🧬

Bacteroides as CF Probiotic

Evolving Bacteroides strains for enhanced fitness in CF-like environments; decoding molecular mechanisms including bile acid resistance via Diversity-Generating Retroelements.

Bacteroides
🔬

Microbial Ecology

Spatial and genomic ecology of Gracilibacteria in green sulfur bacteria enrichment cultures using metagenomics and high-resolution imaging at MBL Woods Hole (2025).

Microbial Ecology
⚗️

Probiotic LAB Biology

Isolated and characterized novel L. plantarum strains; evolved tolerance to furfural and 5-HMF for lignocellulosic fermentations. Three first-author publications.

Probiotic LAB
🌿

Streptococus ruoffii sp. nov.

Isolated and characterized Streptococus ruoffii sp. nov. The new species was isolated from esophagus of adult male heterozygous for CF allele.

Natural Products
💻

Bioinformatics

Genome assembly, annotation, comparative genomics, phylogenetics, transcriptomics, and microbiome analysis using R, Python, and Linux. Metagenomics for complex communities.

Bioinformatics
03 — Publications

Scientific Output

Google Scholar
2026
In Prep

Spatial and Genomic Ecology of Gracilibacteria in Green Sulfur Bacteria Enrichment Cultures

Surve S.V., Eggins S., Day L.A., Huang Y., Kahn A., Charles-Orszag A., Yang J., O'Toole G.A., Dawson S.C., Spear J.R.

In PreparationFirst Author
2026
In Prep
2026

The Regional Landscape of the Human Colon Culturome in Health and Cystic Fibrosis

Surve S.V., Valls R.A., Barrack K.E., Gwilt L.L., Gardner T.B., O'Toole G.A.

Microbiology Spectrum
PublishedFirst Author
2026

Genome Sequences of 109 Gut Bacteria Isolated from Colonoscopy Samples of Individuals with and without Cystic Fibrosis

Surve S.V., Valls R.A., O'Toole G.A.

Microbiology Resource Announcement
PublishedFirst Author
2026
In Review

A Genotoxin Associated with Colorectal Cancer Linked to Gut Dysbiosis in Children with Cystic Fibrosis

Barrack K.E., Surve S.V., Bezerra A.V., Murphy C.E., Soucy S.M., Valls R.A., O'Toole G.A.

mBio
In Review at mBio
2026
In Review

Sex and Intestinal-Region-Specific Bacteroides Regulation of Host Response to Pulmonary Challenge

Valls R.A., Barrack K.E., Surve S.V., Bliska J.B., O'Toole G.A.

mBio
In Review at mBio
2025

Profiling Bile Acids in the Stools of Humans and Animal Models of Cystic Fibrosis

Carmichael M.M., Valls R.A., Soucy S., Sanville J.L., Madan J.L., Surve S.V., Sundrud M.S., O'Toole G.A.

Microbiology Spectrum
Published
2024

Transcriptomic Analysis Identifies a Furfural Reductase in Lactiplantibacillus plantarum

Surve S.V., Rajkhowa R., Vyas P., Vijayvargiya M., Khare S., Kulkarni R.

Biocatalysis and Agricultural Biotechnology, 62, 103449
PublishedFirst Author
2024

Laboratory Domestication of Lactiplantibacillus plantarum Alters Some Phenotypic Traits but Causes Non-Novel Genomic Impact

Surve S.V., Shinde D.B., Fernandes J.M., Sharma S., Vijayvargiya M., Kadam K., Kulkarni R.

Journal of Applied Microbiology, 135(2), lxae035
PublishedFirst Author
2024

An In Vitro Medium for Modeling Gut Dysbiosis Associated with Cystic Fibrosis

Barrack K.E., Hampton T.H., Valls R.A., Surve S.V., Gardner T.B., Sanville J.L., Madan J.L., O'Toole G.A.

Journal of Bacteriology, 206(1), e00286-23
Published
2022

Isolation, Characterization, and Comparative Genomics of Potentially Probiotic Lactiplantibacillus plantarum Strains from Indian Foods

Surve S., Shinde D.B., Kulkarni R.

Scientific Reports, 12(1), 1940
PublishedFirst AuthorTop 100 Microbiology 2022
04 — Education

Academic Journey

Dartmouth
Doctor of Philosophy
Microbiology & Immunology · Geisel School of Medicine at Dartmouth, NH
Aug 2021 – Jun 2027 (Expected)
Thesis: Bacteroides as a potential CF probiotic
Advisor: Dr. George A. O'Toole · Contributing to 2 patent applications
Includes Microbial Diversity Course, MBL Woods Hole (2025)
Symbiosis
Master of Science · Biotechnology
Symbiosis International University, Pune, India
Aug 2016 – Jun 2018
Thesis: Isolation and Characterization of Lactic Acid Bacteria from Indian Foods
PG Merit Scholarship — 50% tuition waiver
GPA 9.21/10 · Rank 1/30
University of Mumbai
Bachelor of Science · Biotechnology
University of Mumbai, India
Aug 2013 – Jun 2016
Foundation in molecular biology, biochemistry, and microbiology
GPA 6.85/7.0 · Rank 4/30
🏆

M2P2 Scholarship

Dartmouth College · Aug 2025 · Off-campus course funding during PhD

🎓

PG Merit Scholarship

Symbiosis International University · 50% tuition waiver as Rank 1 student

🇮🇳

DST INSPIRE Fellowship

Ministry of Science & Technology, Govt. of India · Awarded to top-ranked graduates

📊

CSIR-UGC NET-LS

All India Rank 22 · Highly competitive STEM research fellowship qualification exam

🔭

Summer Research Fellowship

Indian Academy of Sciences · National fellowship for early-career STEM researchers

Veronica Rodriguez Award

Tata Institute of Fundamental Research · Leadership & excellence, CUBE program

Programming

RPythonLinux CLIBash

Bioinformatics

Genome AssemblyAnnotationComparative GenomicsPhylogeneticsTranscriptomicsMicrobiome Analysis

Wet Lab

Molecular CloningCulturomicsBacterial GeneticsExperimental EvolutionMetagenomics

Let's Connect

I'm always happy to discuss my research, potential collaborations, or opportunities in academia and industry. Whether you're interested in gut microbiome science, CF biology, or just want to talk science — feel free to reach out.

I'll be completing my PhD in June 2027 and am actively exploring postdoctoral and industry positions in microbiome science, translational medicine, and biotechnology.

Download CV